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Glucosamine-6-phosphate deaminase 2
Symbols GNPDA2 ; GNP2; SB52
External IDs OMIM613222 MGI1915230 HomoloGene12381 GeneCards: GNPDA2 Gene
EC number
Species Human Mouse
Entrez 132789 67980
Ensembl ENSG00000163281 ENSMUSG00000029209
UniProt Q8TDQ7 Q9CRC9
RefSeq (mRNA) NM_001270880 NM_001038015
RefSeq (protein) NP_001257809 NP_001033104
Location (UCSC) Chr 4:
44.7 – 44.73 Mb
Chr 5:
69.57 – 69.59 Mb
PubMed search [1] [2]

Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an enzyme that in humans is encoded by the GNPDA2 gene.[1]

Clinical significance[edit]

Variants of the GNPDA2 gene may be associated with obesity.[2][3][4]


  1. ^ Arreola R, Valderrama B, Morante ML, Horjales E (September 2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study". FEBS Lett. 551 (1–3): 63–70. doi:10.1016/S0014-5793(03)00896-2. PMID 12965206. 
  2. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring) 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790. 
  3. ^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386. 
  4. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 25–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261. 

Further reading[edit]