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Golgi-associated PDZ and coiled-coil motif containing
Protein GOPC PDB 2dc2.png
PDB rendering based on 2dc2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GOPC ; CAL; FIG; GOPC1; PIST; dJ94G16.2
External IDs OMIM606845 MGI2149946 HomoloGene10695 ChEMBL: 1741218 GeneCards: GOPC Gene
Species Human Mouse
Entrez 57120 94221
Ensembl ENSG00000047932 ENSMUSG00000019861
UniProt Q9HD26 Q8BH60
RefSeq (mRNA) NM_001017408 NM_001199272
RefSeq (protein) NP_001017408 NP_001186201
Location (UCSC) Chr 6:
117.64 – 117.92 Mb
Chr 10:
52.34 – 52.38 Mb
PubMed search [1] [2]

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.[1][2][3]

PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM][3]


GOPC has been shown to interact with GRID2,[4] BECN1,[4] RHOQ,[1] ACCN3,[5] Cystic fibrosis transmembrane conductance regulator[6][7] and CSPG5.[8]


  1. ^ a b Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552. 
  2. ^ Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064. 
  3. ^ a b "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing". 
  4. ^ a b Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron (United States) 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. ISSN 0896-6273. PMID 12372286. 
  5. ^ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. (United States) 279 (45): 46962–8. doi:10.1074/jbc.M405874200. ISSN 0021-9258. PMID 15317815. 
  6. ^ Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". J. Biol. Chem. (United States) 277 (5): 3520–9. doi:10.1074/jbc.M110177200. ISSN 0021-9258. PMID 11707463. 
  7. ^ Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (Feb 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. (United States) 278 (8): 6440–9. doi:10.1074/jbc.M211050200. ISSN 0021-9258. PMID 12471024. 
  8. ^ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. (United States) 278 (41): 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772. 

Further reading[edit]