GOT1

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Glutamic-oxaloacetic transaminase 1, soluble
Protein GOT1 PDB 1ajr.png
PDB rendering based on 1ajr.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GOT1 ; ASTQTL1; GIG18; cAspAT; cCAT
External IDs OMIM138180 MGI95791 HomoloGene1571 GeneCards: GOT1 Gene
EC number 2.6.1.1, 2.6.1.3
RNA expression pattern
PBB GE GOT1 208813 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2805 14718
Ensembl ENSG00000120053 ENSMUSG00000025190
UniProt P17174 P05201
RefSeq (mRNA) NM_002079 NM_010324
RefSeq (protein) NP_002070 NP_034454
Location (UCSC) Chr 10:
101.16 – 101.19 Mb
Chr 19:
43.5 – 43.52 Mb
PubMed search [1] [2]

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.[1][2]

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit|]]
Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

References[edit]

  1. ^ Bousquet-Lemercier B, Pol S, Pave-Preux M, Hanoune J, Barouki R (Sep 1990). "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection". Biochemistry 29 (22): 5293–9. doi:10.1021/bi00474a011. PMID 1974457. 
  2. ^ a b "Entrez Gene: GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)". 

Further reading[edit]