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Glycoprotein A33 (transmembrane)
Symbols GPA33 ; A33
External IDs OMIM602171 MGI1891703 HomoloGene4245 GeneCards: GPA33 Gene
RNA expression pattern
PBB GE GPA33 205929 at tn.png
More reference expression data
Species Human Mouse
Entrez 10223 59290
Ensembl ENSG00000143167 ENSMUSG00000000544
UniProt Q99795 Q9JKA5
RefSeq (mRNA) NM_005814 NM_021610
RefSeq (protein) NP_005805 NP_067623
Location (UCSC) Chr 1:
167.02 – 167.06 Mb
Chr 1:
166.13 – 166.17 Mb
PubMed search [1] [2]

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.[1][2][3]

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[3]


  1. ^ Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A 94 (2): 469–74. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807. 
  2. ^ Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713. 
  3. ^ a b "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)". 

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