GPLD1

Glycosylphosphatidylinositol specific phospholipase D1
Identifiers
Symbols	GPLD1; GPIPLD; GPIPLDM; MGC22590; PIGPLD; PIGPLD1
External IDs	OMIM: 602515 MGI: 106604 HomoloGene: 1152 GeneCards: GPLD1 Gene
EC number	3.1.4.50
Gene Ontology Molecular function • glycosylphosphatidylinositol phospholipase D activity • phospholipase D activity • hydrolase activity Cellular component • extracellular region Biological process • GPI anchor release Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2822	14756
Ensembl	ENSG00000112293	ENSMUSG00000021340
UniProt	P80108	Q5NCE6
RefSeq (mRNA)	NM_001503.2	NM_008156.2
RefSeq (protein)	NP_001494.2	NP_032182.2
Location (UCSC)	Chr 6: 24.42 – 24.5 Mb	Chr 13: 25.04 – 25.08 Mb
PubMed search	[1]	[2]

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

Interactions

GPLD1 has been shown to interact with Apolipoprotein A1 and APOA4.

Further reading

• Hoener MC, Brodbeck U (1992). "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins". Eur. J. Biochem. 206 (3): 747–57. doi:10.1111/j.1432-1033.1992.tb16981.x. PMID 1606959. 
• Scallon BJ, Fung WJ, Tsang TC et al (1991). "Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D". Science 252 (5004): 446–8. doi:10.1126/science.2017684. PMID 2017684. 
• Metz CN, Brunner G, Choi-Muira NH et al (1994). "Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D". EMBO J. 13 (7): 1741–51. PMC 395007. PMID 7512501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395007. 
• Jinnai H, Nakamura S (2000). "Characterization of phospholipase D activation by GM2 activator in a cell-free system". The Kobe journal of medical sciences 45 (3–4): 181–90. PMID 10752311. 
• Deeg MA, Bierman EL, Cheung MC (2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". J. Lipid Res. 42 (3): 442–51. PMID 11254757. 
• Tang J, Li W (2002). "[Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum]". Hunan Yi Ke Da Xue Xue Bao 24 (2): 119–22. PMID 11938765. 
• Slomiany A, Nishikawa H, Slomiany BL (2002). "Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa". J. Physiol. Pharmacol. 53 (1): 21–38. PMID 11939716. 
• Jaworek J, Bonio J, Leja-Szpa A et al (2002). "Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin". J. Physiol. Pharmacol. 53 (1): 51–74. PMID 11939719. 
• Deeg MA, Bowen RF (2002). "Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D". Biochem. Cell Biol. 80 (2): 253–60. doi:10.1139/o02-004. PMID 11989719. 
• Xiaotong H, Hannocks MJ, Hampson I, Brunner G (2002). "GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy". Clin. Exp. Metastasis 19 (4): 291–9. doi:10.1023/A:1015545407700. PMID 12090469. 
• Magnusson P, Sharp CA, Farley JR (2003). "Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts". Clin. Chim. Acta 325 (1–2): 59–70. doi:10.1016/S0009-8981(02)00248-6. PMID 12367767. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tang JH, Gu SL, Zhang XJ (2003). "[Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D]". Hunan Yi Ke Da Xue Xue Bao 26 (2): 95–7. PMID 12536633. 
• Mungall AJ, Palmer SA, Sims SK et al (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Kurtz TA, Fineberg NS, Considine RV, Deeg MA (2004). "Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D". Metab. Clin. Exp. 53 (2): 138–9. doi:10.1016/j.metabol.2003.09.004. PMID 14767861. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lugli EB, Pouliot M, Portela Mdel P et al (2005). "Characterization of primate trypanosome lytic factors". Mol. Biochem. Parasitol. 138 (1): 9–20. doi:10.1016/j.molbiopara.2004.07.004. PMID 15500911. 
• Everett PB, Senogles SE (2005). "D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway". Neurosci. Lett. 371 (1): 34–9. doi:10.1016/j.neulet.2004.08.033. PMID 15500962. 
• Mead KI, Zheng Y, Manzotti CN et al (2005). "Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells". J. Immunol. 174 (8): 4803–11. PMID 15814706.