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G protein-coupled receptor 101
Symbols GPR101 ; GPCR6
External IDs OMIM300393 MGI2685211 HomoloGene14273 IUPHAR: 125 GeneCards: GPR101 Gene
RNA expression pattern
PBB GE GPR101 gnf1h01265 at tn.png
More reference expression data
Species Human Mouse
Entrez 83550 245424
Ensembl ENSG00000165370 ENSMUSG00000036357
UniProt Q96P66 Q80T62
RefSeq (mRNA) NM_054021 NM_001033360
RefSeq (protein) NP_473362 NP_001028532
Location (UCSC) Chr X:
137.03 – 137.03 Mb
Chr X:
57.5 – 57.5 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[2]

Clinical significance[edit]

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[3]


  1. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  2. ^ a b "Entrez Gene: GPR101 G protein-coupled receptor 101". 
  3. ^ Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO et al. (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. doi:10.1056/NEJMoa1408028. PMID 25470569. 

Further reading[edit]

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.