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G protein-coupled receptor 112
Symbols GPR112 ; PGR17; RP1-299I16
External IDs MGI3643431 HomoloGene72131 IUPHAR: GPR112 GeneCards: GPR112 Gene
Species Human Mouse
Entrez 139378 236798
Ensembl ENSG00000156920 ENSMUSG00000053852
UniProt Q8IZF6 B7ZCC9
RefSeq (mRNA) NM_153834 NM_001033327
RefSeq (protein) NP_722576 n/a
Location (UCSC) Chr X:
135.38 – 135.52 Mb
Chr X:
56.87 – 57 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 112 is a protein that in humans is encoded by the GPR112 gene.[1]

The gene product is a member of the adhesion-GPCR family of receptors.[2] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]


  1. ^ "Entrez Gene: GPR112 G protein-coupled receptor 112". 
  2. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  3. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

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