GPR112

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G protein-coupled receptor 112
Identifiers
Symbols GPR112 ; PGR17; RP1-299I16
External IDs MGI3643431 HomoloGene72131 IUPHAR: 192 GeneCards: GPR112 Gene
Orthologs
Species Human Mouse
Entrez 139378 236798
Ensembl ENSG00000156920 ENSMUSG00000053852
UniProt Q8IZF6 B7ZCC9
RefSeq (mRNA) NM_153834 NM_001033327
RefSeq (protein) NP_722576 n/a
Location (UCSC) Chr X:
135.38 – 135.52 Mb
Chr X:
56.87 – 57 Mb
PubMed search [1] [2]

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.[1][2] GPR112 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

GPR112 is expressed in human enterochromaffin cells[6] and in the mouse intestine.[7] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.[8] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[9]

References[edit]

  1. ^ "Entrez Gene: GPR112 G protein-coupled receptor 112". 
  2. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  6. ^ Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH et al. (Feb 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology 22 (2): 261–72. doi:10.1038/modpathol.2008.174. PMID 18953328. 
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  9. ^ Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH et al. (Feb 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology 22 (2): 261–72. doi:10.1038/modpathol.2008.174. PMID 18953328. 

External links[edit]