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G protein-coupled receptor 114
Symbols GPR114 ; PGR27
External IDs MGI2685955 HomoloGene17828 IUPHAR: 194 GeneCards: GPR114 Gene
Species Human Mouse
Entrez 221188 382045
Ensembl ENSG00000159618 ENSMUSG00000061577
UniProt Q8IZF4 Q3V3Z3
RefSeq (mRNA) NM_153837 NM_001033468
RefSeq (protein) NP_722579 NP_001028640
Location (UCSC) Chr 16:
57.58 – 57.63 Mb
Chr 8:
94.92 – 94.94 Mb
PubMed search [1] [2]

G-protein coupled receptor 114 also known as ADGRG5 is a protein that in humans is encoded by the GPR114 gene.[1][2] The gene product is a member of the adhesion-GPCR family of receptors.[3] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[5]


The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[6]


  1. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". 
  2. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ a b Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  5. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  6. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–9. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. 

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