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Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.[1][2][3] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.[4][5]


  1. ^ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4. 
  2. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ "Entrez Gene: GPR116 G protein-coupled receptor 116". 
  4. ^ Yang, MY; Hilton, MB; Seaman, S; Haines, DC; Nagashima, K; Burks, CM; Tessarollo, L; Ivanova, PT; Brown, HA; Umstead, TM; Floros, J; Chroneos, ZC; St Croix, B (May 30, 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.". Cell reports 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMID 23684610. 
  5. ^ Fukuzawa, T; Ishida, J; Kato, A; Ichinose, T; Ariestanti, DM; Takahashi, T; Ito, K; Abe, J; Suzuki, T; Wakana, S; Fukamizu, A; Nakamura, N; Hirose, S (2013). "Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D.". PloS one 8 (7): e69451. doi:10.1371/journal.pone.0069451. PMID 23922714. 

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