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Free fatty acid receptor 4
Symbols FFAR4 ; BMIQ10; GPR120; GPR129; GT01; O3FAR1; PGR4
External IDs OMIM609044 MGI2147577 HomoloGene18769 IUPHAR: ChEMBL: 5339 GeneCards: FFAR4 Gene
Species Human Mouse
Entrez 338557 107221
Ensembl ENSG00000186188 ENSMUSG00000054200
UniProt Q5NUL3 Q7TMA4
RefSeq (mRNA) NM_001195755 NM_181748
RefSeq (protein) NP_001182684 NP_861413
Location (UCSC) Chr 10:
95.33 – 95.36 Mb
Chr 19:
38.1 – 38.11 Mb
PubMed search [1] [2]

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM][2]

GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity[4]


  1. ^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. 
  2. ^ a b "Entrez Gene: GPR120 G protein-coupled receptor 120". 
  3. ^ Oh Da, Y.; Talukdar, S.; Bae, E.; Imamura, T.; Morinaga, H.; Fan, W.; Li, P.; Lu, W.; Watkins, S.; Olefsky, J. M. (2010). "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell 142 (5): 687–698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258.  edit
  4. ^ Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Further reading[edit]