GPR128

From Wikipedia, the free encyclopedia
Jump to: navigation, search
G protein-coupled receptor 128
Identifiers
Symbols GPR128 ; FLJ14454; FLJ16382; FLJ29035; MGC142011; MGC163260
External IDs OMIM612307 MGI2441732 HomoloGene13115 IUPHAR: 201 GeneCards: GPR128 Gene
RNA expression pattern
PBB GE GPR128 gnf1h00942 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84873 239853
Ensembl ENSG00000144820 ENSMUSG00000022755
UniProt Q96K78 Q8BM96
RefSeq (mRNA) NM_032787 NM_172825
RefSeq (protein) NP_116176 NP_766413
Location (UCSC) Chr 3:
100.33 – 100.41 Mb
Chr 16:
56.72 – 56.8 Mb
PubMed search [1] [2]

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.[1][2][3] GPR128 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[7]

Function[edit]

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[8]

Clinical significance[edit]

A 111-kb amplification with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[9] Notably, the fused gene was also detected in few healthy individuals.

References[edit]

  1. ^ "Entrez Gene: GPR128 G protein-coupled receptor 128". 
  2. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  4. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  6. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ^ Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL et al. (Jan 2014). "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology 20 (2): 498–508. doi:10.3748/wjg.v20.i2.498. PMID 24574718. 
  9. ^ Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P et al. (Jan 2010). "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica 95 (1): 20–6. doi:10.3324/haematol.2009.011536. PMID 19797732. 

External links[edit]