GPR143

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G protein-coupled receptor 143
Identifiers
Symbols GPR143 ; NYS6; OA1
External IDs OMIM300808 MGI107193 HomoloGene230 IUPHAR: 203 GeneCards: GPR143 Gene
RNA expression pattern
PBB GE GPR143 206696 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4935 18241
Ensembl ENSG00000101850 ENSMUSG00000025333
UniProt P51810 P70259
RefSeq (mRNA) NM_000273 NM_010951
RefSeq (protein) NP_000264 NP_035081
Location (UCSC) Chr X:
9.69 – 9.75 Mb
Chr X:
152.78 – 152.81 Mb
PubMed search [1] [2]
Ocular albinism type 1 protein
Identifiers
Symbol Ocular_alb
Pfam PF02101
Pfam clan CL0192
InterPro IPR001414

G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.[1][2][3]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[3]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[4][5]

L-DOPA is an endogenous ligand for OA1.[6]

Interactions[edit]

GPR143 has been shown to interact with GNAI1.[2]

References[edit]

  1. ^ Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet 10 (1): 13–9. doi:10.1038/ng0595-13. PMID 7647783. 
  2. ^ a b Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. 
  3. ^ a b "Entrez Gene: GPR143 G protein-coupled receptor 143". 
  4. ^ Vetrini F, Auricchio A, Du J et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. doi:10.1128/MCB.24.15.6550-6559.2004. PMC 444869. PMID 15254223. 
  5. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  6. ^ Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh, Gregory S., ed. "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. doi:10.1371/journal.pbio.0060236. PMC 2553842. PMID 18828673. 

Further reading[edit]

External links[edit]