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G protein-coupled receptor 158
Symbols GPR158 ; RP11-59G22.1
External IDs OMIM614573 MGI2441697 HomoloGene19381 IUPHAR: 210 GeneCards: GPR158 Gene
RNA expression pattern
PBB GE GPR158 gnf1h10155 at tn.png
More reference expression data
Species Human Mouse
Entrez 57512 241263
Ensembl ENSG00000151025 ENSMUSG00000045967
UniProt Q5T848 Q8C419
RefSeq (mRNA) NM_020752 NM_001004761
RefSeq (protein) NP_065803 NP_001004761
Location (UCSC) Chr 10:
25.46 – 25.89 Mb
Chr 2:
21.37 – 21.83 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]

GPR158 is an orphan class C GPCR. It is highly expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]

GPR158 is also expressed at lower levels in other organs and has been linked to neuroendocrine differentiation. It shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[3]