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G protein-coupled receptor 158
Symbols GPR158 ; RP11-59G22.1
External IDs OMIM614573 MGI2441697 HomoloGene19381 IUPHAR: GPR158 GeneCards: GPR158 Gene
RNA expression pattern
PBB GE GPR158 gnf1h10155 at tn.png
More reference expression data
Species Human Mouse
Entrez 57512 241263
Ensembl ENSG00000151025 ENSMUSG00000045967
UniProt Q5T848 Q8C419
RefSeq (mRNA) NM_020752 NM_001004761
RefSeq (protein) NP_065803 NP_001004761
Location (UCSC) Chr 10:
25.46 – 25.89 Mb
Chr 2:
21.37 – 21.83 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]

GPR158 is an orphan class C GPCR. It is specifically expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]


  1. ^ "Entrez Gene: GPR158 G protein-coupled receptor 158". 
  2. ^ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.