GPR158

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G protein-coupled receptor 158
Identifiers
Symbols GPR158 ; RP11-59G22.1
External IDs OMIM614573 MGI2441697 HomoloGene19381 IUPHAR: GPR158 GeneCards: GPR158 Gene
RNA expression pattern
PBB GE GPR158 gnf1h10155 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57512 241263
Ensembl ENSG00000151025 ENSMUSG00000045967
UniProt Q5T848 Q8C419
RefSeq (mRNA) NM_020752 NM_001004761
RefSeq (protein) NP_065803 NP_001004761
Location (UCSC) Chr 10:
25.46 – 25.89 Mb
Chr 2:
21.37 – 21.83 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 158 is a protein that in humans is encoded by the GPR158 gene.[1]

GPR158 is an orphan class C GPCR. It is specifically expressed in the brain where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[2]

References[edit]

  1. ^ "Entrez Gene: GPR158 G protein-coupled receptor 158". 
  2. ^ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.