GPR3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
G protein-coupled receptor 3
Identifiers
Symbols GPR3 ; ACCA
External IDs OMIM600241 MGI101908 HomoloGene31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
RNA expression pattern
PBB GE GPR3 214613 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2827 14748
Ensembl ENSG00000181773 ENSMUSG00000049649
UniProt P46089 P35413
RefSeq (mRNA) NM_005281 NM_008154
RefSeq (protein) NP_005272 NP_032180
Location (UCSC) Chr 1:
27.72 – 27.72 Mb
Chr 4:
133.21 – 133.21 Mb
PubMed search [1] [2]

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][2] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function[edit]

GPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[5][6] however this result was not confirmed in a β-arrestin recruitment assay.[7]

References[edit]

  1. ^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889. 
  2. ^ "Entrez Gene: GPR3 G protein-coupled receptor 3". 
  3. ^ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3) (Pt 3): 837–43. PMC 1135708. PMID 7639700. 
  4. ^ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206. 
  5. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cell. Signal. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  6. ^ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830. 
  7. ^ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). "Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay". J. Biol. Chem. 284 (18): 12328–38. doi:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662. 

Further reading[edit]