GPR44

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Prostaglandin D2 receptor 2
Identifiers
Symbols PTGDR2 ; CD294; CRTH2; DL1R; DP2; GPR44
External IDs OMIM604837 MGI1330275 HomoloGene3508 IUPHAR: DP2 ChEMBL: 5071 GeneCards: PTGDR2 Gene
RNA expression pattern
PBB GE GPR44 206361 at tn.png
PBB GE GPR44 216464 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11251 14764
Ensembl ENSG00000183134 ENSMUSG00000034117
UniProt Q9Y5Y4 Q9Z2J6
RefSeq (mRNA) NM_004778 NM_009962
RefSeq (protein) NP_004769 NP_034092
Location (UCSC) Chr 11:
60.62 – 60.62 Mb
Chr 19:
10.94 – 10.94 Mb
PubMed search [1] [2]

G protein-coupled receptor 44 (GPR44) is a human protein.[1] GPR44 has also been designated as CD294 (cluster of differentiation 294).

G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][1]

GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature.

GPR44 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the PGD2-GPR44 pathway as a potential target for bald treatment.[2] A particularly promising compound for blocking the PGD2-GPR44 pathway is a compound known as TM-30089, which exhibits a "functional insurmountability" of PGD2 expression.[3]

References[edit]

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.