GPR50

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G protein-coupled receptor 50
Identifiers
Symbols GPR50 ; H9; Mel1c
External IDs OMIM300207 MGI1333877 HomoloGene3113 IUPHAR: GPR50 GeneCards: GPR50 Gene
RNA expression pattern
PBB GE GPR50 208311 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9248 14765
Ensembl ENSG00000102195 ENSMUSG00000056380
UniProt Q13585 O88495
RefSeq (mRNA) NM_004224 NM_010340
RefSeq (protein) NP_004215 NP_034470
Location (UCSC) Chr X:
150.35 – 150.35 Mb
Chr X:
71.66 – 71.67 Mb
PubMed search [1] [2]

G protein-coupled receptor 50 is a protein which in humans is encoded by the GPR50 gene.[1][2][3]

Function[edit]

GPR50 is a member of the G protein-coupled receptor family of integral membrane proteins and is most closely related to the melatonin receptor.[2] GPR50 is able to heterodimerize with both the MT1 and MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding melatonin and coupling to G proteins.[4] GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates. [5]

Clinical significance[edit]

Certain polymorphisms of the GPR50 gene in females are associated with increased risk of developing bipolar affective disorder, major depressive disorder, and schizophrenia.[6] Other GPR50 gene polymorphism are associated with higher fasting circulating triglyceride levels and lower circulating High-density lipoprotein levels.[7]

References[edit]

  1. ^ "Entrez Gene: GPR50 G protein-coupled receptor 50". 
  2. ^ a b Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). "Cloning of a melatonin-related receptor from human pituitary". FEBS Letters 386 (2–3): 219–24. doi:10.1016/0014-5793(96)00437-1. PMID 8647286. 
  3. ^ Gubitz AK, Reppert SM (January 1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics 55 (2): 248–51. doi:10.1006/geno.1998.5661. PMID 9933574. 
  4. ^ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization". The EMBO Journal 25 (13): 3012–23. doi:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767. 
  5. ^ Dufourny L, Levasseur A, Migaud M, Callebaut I, Pontarotti P, Malpaux B, Monget P. (2008). "GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals". BMC Evolutionary Biology 8: 105. doi:10.1186/1471-2148-8-105. PMC 2323367. PMID 18400093. 
  6. ^ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). "Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor". Molecular psychiatry 10 (5): 470–8. doi:10.1038/sj.mp.4001593. PMID 15452587. 
  7. ^ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). "Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels". Journal of lipid research 47 (4): 761–6. doi:10.1194/jlr.M500338-JLR200. PMID 16436372. 

Further reading[edit]