G-protein coupled receptor 56 is a protein that in humans is encoded by the GPR56gene. The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development,. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells
In melanocytic cells GPR56 gene expression may be regulated by MITF.
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