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Complement component 5a receptor 2
Symbols C5AR2 ; C5L2; GPF77; GPR77
External IDs OMIM609949 MGI2442013 HomoloGene49549 IUPHAR: 33 GeneCards: C5AR2 Gene
RNA expression pattern
PBB GE GPR77 221149 at tn.png
More reference expression data
Species Human Mouse
Entrez 27202 319430
Ensembl ENSG00000134830 ENSMUSG00000074361
UniProt Q9P296 Q8BW93
RefSeq (mRNA) NM_001271749 NM_001146005
RefSeq (protein) NP_001258678 NP_001139477
Location (UCSC) Chr 19:
47.84 – 47.85 Mb
Chr 7:
16.23 – 16.24 Mb
PubMed search [1] [2]

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.[1][2]


The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.[2][3]


  1. ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367. 
  2. ^ a b "HUGO". 
  3. ^ Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID 16204243. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.