GPRC6A

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G protein-coupled receptor, class C, group 6, member A
Identifiers
Symbols GPRC6A ; GPCR; bA86F4.3
External IDs OMIM613572 MGI2429498 HomoloGene17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene
Orthologs
Species Human Mouse
Entrez 222545 210198
Ensembl ENSG00000173612 ENSMUSG00000019905
UniProt Q5T6X5 Q8K4Z6
RefSeq (mRNA) NM_001286354 NM_153071
RefSeq (protein) NP_001273283 NP_694711
Location (UCSC) Chr 6:
117.11 – 117.15 Mb
Chr 10:
51.61 – 51.63 Mb
PubMed search [1] [2]

G protein-coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene.[1] This receptor functions as a sensor of L-amino acids,[2] calcium,[3] osteocalcin,[4] and steroids.[5]

Clinical significance[edit]

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediated rapid, non-genomic prostate cancer cell responses to testosterone.[6]

References[edit]

  1. ^ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A". 
  2. ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. 
  3. ^ Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol Chem 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532. 
  4. ^ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMID 21425331. 
  5. ^ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496. 
  6. ^ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate 72 (4): 399–409. doi:10.1002/pros.21442. PMID 21681779. 

Further reading[edit]

  • Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188. 
  • Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. 
  • Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532. 

External links[edit]