GPS2 (gene)

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G protein pathway suppressor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GPS2 ; AMF-1
External IDs OMIM601935 MGI1891751 HomoloGene49599 GeneCards: GPS2 Gene
Species Human Mouse
Entrez 2874 56310
Ensembl ENSG00000132522 ENSMUSG00000023170
UniProt Q13227 Q921N8
RefSeq (mRNA) NM_004489 NM_019726
RefSeq (protein) NP_004480 NP_062700
Location (UCSC) Chr 17:
7.21 – 7.22 Mb
Chr 11:
69.91 – 69.92 Mb
PubMed search [1] [2]

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.[1][2]

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[2]


GPS2 (gene) has been shown to interact with Cyclin A1,[3] TBL1X,[4] Nuclear receptor co-repressor 1,[4][5][6] P53,[7] EP300,[8] HDAC3[4] and C21orf7.[9]


  1. ^ Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J (January 1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Mol Cell Biol 16 (12): 6698–706. PMC 231672. PMID 8943324. 
  2. ^ a b "Entrez Gene: GPS2 G protein pathway suppressor 2". 
  3. ^ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (August 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402. 
  4. ^ a b c Zhang, Jinsong; Kalkum Markus; Chait Brian T; Roeder Robert G (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell (United States) 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. ISSN 1097-2765. PMID 11931768. 
  5. ^ Yoon, Ho-Geun; Chan Doug W; Reynolds Albert B; Qin Jun; Wong Jiemin (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell (United States) 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. ISSN 1097-2765. PMID 14527417. 
  6. ^ Yoon, Ho-Geun; Chan Doug W; Huang Zhi-Qing; Li Jiwen; Fondell Joseph D; Qin Jun; Wong Jiemin (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. (England) 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMC 151047. PMID 12628926. 
  7. ^ Peng, Y C; Kuo F; Breiding D E; Wang Y F; Mansur C P; Androphy E J (September 2001). "AMF1 (GPS2) modulates p53 transactivation". Mol. Cell. Biol. (United States) 21 (17): 5913–24. doi:10.1128/MCB.21.17.5913-5924.2001. ISSN 0270-7306. PMC 87310. PMID 11486030. 
  8. ^ Peng, Y C; Breiding D E; Sverdrup F; Richard J; Androphy E J (July 2000). "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". J. Virol. (UNITED STATES) 74 (13): 5872–9. doi:10.1128/JVI.74.13.5872-5879.2000. ISSN 0022-538X. PMC 112082. PMID 10846067. 
  9. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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