G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2gene.
Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]
^Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J Biol Chem277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID11832491.
^ abMochizuki N, Cho G, Wen B, Insel PA (Jan 1997). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID8973305.
Du Q, Stukenberg PT, Macara IG (2002). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol.3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID11781568.
Yasumi M, Sakisaka T, Hoshino T et al. (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem.280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID15632202.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun.341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID16458856.