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G-protein signaling modulator 2
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM609245 MGI1923373 HomoloGene56584 GeneCards: GPSM2 Gene
RNA expression pattern
PBB GE GPSM2 205240 at tn.png
PBB GE GPSM2 221922 at tn.png
More reference expression data
Species Human Mouse
Entrez 29899 76123
Ensembl ENSG00000121957 ENSMUSG00000027883
UniProt P81274 Q8VDU0
RefSeq (mRNA) NM_013296 NM_029522
RefSeq (protein) NP_037428 NP_083798
Location (UCSC) Chr 1:
109.42 – 109.47 Mb
Chr 3:
108.68 – 108.72 Mb
PubMed search [1] [2]

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[1][2][3]

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][3]


GPSM2 has been shown to interact with Nuclear mitotic apparatus protein 1[4] and GNAI2.[2][5]


  1. ^ Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J Biol Chem 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491. 
  2. ^ a b Mochizuki N, Cho G, Wen B, Insel PA (Jan 1997). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305. 
  3. ^ a b "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)". 
  4. ^ Du, Q; Stukenberg P T; Macara I G (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. (England) 3 (12): 1069–75. doi:10.1038/ncb1201-1069. ISSN 1465-7392. PMID 11781568. 
  5. ^ Marty, Caroline; Browning Darren D; Ye Richard D (Jun 2003). "Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras". Mol. Cell. Biol. (United States) 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. ISSN 0270-7306. PMC 155206. PMID 12748287. 

Further reading[edit]