GPVI

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Glycoprotein VI (platelet)

PDB rendering based on 2gi7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GP6 ; BDPLT11; GPIV; GPVI
External IDs OMIM605546 MGI1889810 HomoloGene9488 GeneCards: GP6 Gene
RNA expression pattern
PBB GE GP6 220336 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51206 243816
Ensembl ENSG00000088053 ENSMUSG00000078810
UniProt Q9HCN6 P0C191
RefSeq (mRNA) NM_001083899 NM_001163014
RefSeq (protein) NP_001077368 NP_001156486
Location (UCSC) Chr 19:
55.53 – 55.55 Mb
Chr 7:
4.37 – 4.4 Mb
PubMed search [1] [2]

Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.[1]

Function[edit]

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.[2][3]

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions[edit]

GPVI has been shown to interact with LYN.[4]

See also[edit]

References[edit]

  1. ^ Ezumi Y, Uchiyama T, Takayama H (October 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochem. Biophys. Res. Commun. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634. 
  2. ^ "Entrez Gene: GP6 glycoprotein VI (platelet)". 
  3. ^ Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (September 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood 96 (5): 1798–807. PMID 10961879. 
  4. ^ Suzuki-Inoue, Katsue; Tulasne David, Shen Yang, Bori-Sanz Teresa, Inoue Osamu, Jung Stephanie M, Moroi Masaaki, Andrews Robert K, Berndt Michael C, Watson Steve P (Jun 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". J. Biol. Chem. (United States) 277 (24): 21561–6. doi:10.1074/jbc.M201012200. ISSN 0021-9258. PMID 11943772. 

Further reading[edit]


External links[edit]