GRAM domain

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GRAM domain
1zvr.gif
Myotubularin-related protein 2
Identifiers
Symbol GRAM
Pfam PF02893
Pfam clan CL0266
InterPro IPR004182
SMART GRAM
SCOP 1lw3
SUPERFAMILY 1lw3
OPM superfamily 176
OPM protein 1zvr

The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins.[1] The structure of the GRAM domain is similar to that found in PH domains.[2]

Human proteins containing this domain[edit]

DIP; GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2; GRAMD3; MTM1; MTMR1; MTMR2; NCOA7; NSMAF; OXR1; SBF1; SBF2; TBC1D8; TBC1D8B; TBC1D9; TBC1D9B; WBP2; WBP2NL; dJ439F8.1;

References[edit]

  1. ^ Doerks T, Strauss M, Brendel M, Bork P (October 2000). "GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins". Trends Biochem. Sci. 25 (10): 483–5. doi:10.1016/S0968-0004(00)01664-9. PMID 11050430. 
  2. ^ Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (December 2003). "Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome". Mol. Cell 12 (6): 1391–402. doi:10.1016/S1097-2765(03)00486-6. PMID 14690594.