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GRB2-related adaptor protein
Symbols GRAP ; MGC64880
External IDs OMIM604330 MGI1918770 HomoloGene4822 GeneCards: GRAP Gene
RNA expression pattern
PBB GE GRAP 206620 at tn.png
More reference expression data
Species Human Mouse
Entrez 10750 71520
Ensembl ENSG00000154016 ENSMUSG00000004837
UniProt Q13588 Q9CX99
RefSeq (mRNA) NM_006613 NM_027817
RefSeq (protein) NP_006604 NP_082093
Location (UCSC) Chr 17:
18.92 – 18.95 Mb
Chr 11:
61.65 – 61.67 Mb
PubMed search [1] [2]

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[1][2][3]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[3]


GRAP has been shown to interact with Linker of activated T cells.[4][5]


  1. ^ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (Jul 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J Biol Chem 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. PMID 8647802. 
  2. ^ Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Feb 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J Biol Chem 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379. 
  3. ^ a b "Entrez Gene: GRAP GRB2-related adaptor protein". 
  4. ^ Zhang, W; Sloan-Lancaster J; Kitchen J; Trible R P; Samelson L E (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. ISSN 0092-8674. PMID 9489702. 
  5. ^ Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732–40. doi:10.1021/bi025554o. ISSN 0006-2960. PMID 12186560. 

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