GRAP

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GRB2-related adaptor protein
Identifiers
Symbols GRAP ; MGC64880
External IDs OMIM604330 MGI1918770 HomoloGene4822 GeneCards: GRAP Gene
RNA expression pattern
PBB GE GRAP 206620 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10750 71520
Ensembl ENSG00000154016 ENSMUSG00000004837
UniProt Q13588 Q9CX99
RefSeq (mRNA) NM_006613 NM_027817
RefSeq (protein) NP_006604 NP_082093
Location (UCSC) Chr 17:
18.92 – 18.95 Mb
Chr 11:
61.65 – 61.67 Mb
PubMed search [1] [2]

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[1][2][3]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[3]

Interactions[edit]

GRAP has been shown to interact with Linker of activated T cells.[4][5]

References[edit]

  1. ^ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (Jul 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J Biol Chem 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. PMID 8647802. 
  2. ^ Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Feb 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J Biol Chem 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379. 
  3. ^ a b "Entrez Gene: GRAP GRB2-related adaptor protein". 
  4. ^ Zhang, W; Sloan-Lancaster J; Kitchen J; Trible R P; Samelson L E (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. ISSN 0092-8674. PMID 9489702. 
  5. ^ Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732–40. doi:10.1021/bi025554o. ISSN 0006-2960. PMID 12186560. 

Further reading[edit]