GRB7

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Growth factor receptor-bound protein 7
Protein GRB7 PDB 1mw4.png
PDB rendering based on 1mw4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol GRB7
External IDs OMIM601522 MGI102683 HomoloGene3881 ChEMBL: 1649051 GeneCards: GRB7 Gene
RNA expression pattern
PBB GE GRB7 210761 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2886 14786
Ensembl ENSG00000141738 ENSMUSG00000019312
UniProt Q14451 Q03160
RefSeq (mRNA) NM_001030002 NM_010346
RefSeq (protein) NP_001025173 NP_034476
Location (UCSC) Chr 17:
37.89 – 37.9 Mb
Chr 11:
98.45 – 98.46 Mb
PubMed search [1] [2]

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.[1][2]

Function[edit]

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.[1]

Clinical significance[edit]

GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in migration[citation needed], is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.

Interactions[edit]

GRB7 has been shown to interact with Insulin receptor,[3] PTK2,[4] RET proto-oncogene,[5] Rnd1[6] and EPH receptor B1.[7]

References[edit]

  1. ^ a b "Entrez Gene: GRB7 growth factor receptor-bound protein 7". 
  2. ^ Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (August 1998). "A novel variant of human Grb7 is associated with invasive esophageal carcinoma". J. Clin. Invest. 102 (4): 821–7. doi:10.1172/JCI2921. PMC 508945. PMID 9710451. 
  3. ^ Kasus-Jacobi, A; Béréziat V; Perdereau D; Girard J; Burnol A F (April 2000). "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2". Oncogene (ENGLAND) 19 (16): 2052–9. doi:10.1038/sj.onc.1203469. ISSN 0950-9232. PMID 10803466. 
  4. ^ Han, D C; Guan J L (August 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". J. Biol. Chem. (UNITED STATES) 274 (34): 24425–30. doi:10.1074/jbc.274.34.24425. ISSN 0021-9258. PMID 10446223. 
  5. ^ Pandey, A; Liu X; Dixon J E; Di Fiore P P; Dixit V M (May 1996). "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". J. Biol. Chem. (UNITED STATES) 271 (18): 10607–10. doi:10.1074/jbc.271.18.10607. ISSN 0021-9258. PMID 8631863. 
  6. ^ Vayssière, B; Zalcman G; Mahé Y; Mirey G; Ligensa T; Weidner K M; Chardin P; Camonis J (February 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. (NETHERLANDS) 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. ISSN 0014-5793. PMID 10664463. 
  7. ^ Han, Dong Cho; Shen Tang-Long; Miao Hui; Wang Bingcheng; Guan Jun-Lin (November 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. (United States) 277 (47): 45655–61. doi:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469. 

Further reading[edit]

External links[edit]