GRIA1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Glutamate receptor, ionotropic, AMPA 1
Identifiers
Symbols GRIA1 ; GLUH1; GLUR1; GLURA; GluA1; HBGR1
External IDs OMIM138248 MGI95808 HomoloGene20226 IUPHAR: GluA1 ChEMBL: 2009 GeneCards: GRIA1 Gene
Orthologs
Species Human Mouse
Entrez 2890 14799
Ensembl ENSG00000155511 ENSMUSG00000020524
UniProt P42261 P23818
RefSeq (mRNA) NM_000827 NM_001113325
RefSeq (protein) NP_000818 NP_001106796
Location (UCSC) Chr 5:
152.87 – 153.19 Mb
Chr 11:
57.01 – 57.33 Mb
PubMed search [1] [2]

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.[1][1][2][2]

Function[edit]

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.[3]

Interactions[edit]

GRIA1 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L (October 1991). "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A 88 (17): 7557–61. doi:10.1073/pnas.88.17.7557. PMC 52340. PMID 1652753. 
  2. ^ a b McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (July 1992). "Chromosomal localization of human glutamate receptor genes". J Neurosci 12 (7): 2555–62. PMID 1319477. 
  3. ^ "Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1". 
  4. ^ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M (November 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. 278 (45): 44745–52. doi:10.1074/jbc.M303576200. PMID 12933808. 
  5. ^ Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW (July 1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". J. Biol. Chem. 273 (31): 19518–24. doi:10.1074/jbc.273.31.19518. PMID 9677374. 
  6. ^ Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ (October 2001). "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway". J. Neurosci. 21 (19): 7506–16. PMID 11567040. 
  7. ^ Shen L, Liang F, Walensky LD, Huganir RL (November 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". J. Neurosci. 20 (21): 7932–40. PMID 11050113. 
  8. ^ Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M (January 2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/s0169-328x(02)00561-2. PMID 12573530. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.