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Glutamate receptor, ionotropic, kainate 5
Symbols GRIK5 ; EAA2; GRIK2; GluK5; KA2
External IDs OMIM600283 MGI95818 HomoloGene1578 IUPHAR: 454 ChEMBL: 2675 GeneCards: GRIK5 Gene
RNA expression pattern
PBB GE GRIK5 214966 at tn.png
PBB GE GRIK5 217509 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2901 14809
Ensembl ENSG00000105737 ENSMUSG00000003378
UniProt Q16478 Q61626
RefSeq (mRNA) NM_001301030 NM_008168
RefSeq (protein) NP_001287959 NP_032194
Location (UCSC) Chr 19:
42.5 – 42.57 Mb
Chr 7:
25.01 – 25.07 Mb
PubMed search [1] [2]

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2]


This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]


GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6]

See also[edit]


  1. ^ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A 91 (25): 11849–53. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545. 
  2. ^ a b "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5". 
  3. ^ Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111. 
  4. ^ Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. 
  5. ^ Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. PMID 8288598. 
  6. ^ Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.