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G protein-coupled receptor kinase 4
Symbols GRK4 ; GPRK2L; GPRK4; GRK4a; IT11
External IDs OMIM137026 MGI95801 HomoloGene23158 IUPHAR: 1468 ChEMBL: 5861 GeneCards: GRK4 Gene
EC number
RNA expression pattern
PBB GE GRK4 208365 s at tn.png
PBB GE GRK4 210600 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2868 14772
Ensembl ENSG00000125388 ENSMUSG00000052783
UniProt P32298 O70291
RefSeq (mRNA) NM_001004056 NM_001080743
RefSeq (protein) NP_001004056 NP_001074212
Location (UCSC) Chr 4:
2.97 – 3.04 Mb
Chr 5:
34.66 – 34.76 Mb
PubMed search [1] [2]

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.[1][2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.[2]


  1. ^ Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet 1 (9): 697–703. doi:10.1093/hmg/1.9.697. PMID 1338872. 
  2. ^ a b "Entrez Gene: GRK4 G protein-coupled receptor kinase 4". 

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