GSK3A

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Glycogen synthase kinase 3 alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSK3A ; DKFZp686D0638
External IDs OMIM606784 MGI2152453 HomoloGene88581 ChEMBL: 2850 GeneCards: GSK3A Gene
EC number 2.7.11.1, 2.7.11.26
RNA expression pattern
PBB GE GSK3A 632 at tn.png
PBB GE GSK3A 202210 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2931 606496
Ensembl ENSG00000105723 ENSMUSG00000057177
UniProt P49840 Q2NL51
RefSeq (mRNA) NM_019884 NM_001031667
RefSeq (protein) NP_063937 NP_001026837
Location (UCSC) Chr 19:
42.73 – 42.75 Mb
Chr 7:
25.23 – 25.24 Mb
PubMed search [1] [2]

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.[1]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.[2][3]

Model organisms[edit]

Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3atm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.[4]

See also[edit]

References[edit]

  1. ^ Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Dec 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID 9809441. 
  2. ^ Ali A, Hoeflich KP, Woodgett JR (August 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387. 
  3. ^ "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha". 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  9. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.