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G1 to S phase transition 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GSPT2 ; ERF3B; GST2
External IDs OMIM300418 MGI1316727 HomoloGene99786 GeneCards: GSPT2 Gene
RNA expression pattern
PBB GE GSPT2 205541 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23708 14853
Ensembl ENSG00000189369 ENSMUSG00000071723
UniProt Q8IYD1 Q149F3
RefSeq (mRNA) NM_018094 NM_008179
RefSeq (protein) NP_060564 NP_032205
Location (UCSC) Chr HG1433_PATCH:
51.49 – 51.49 Mb
Chr X:
94.64 – 94.64 Mb
PubMed search [1] [2]

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.[1][2]

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM][2]


GSPT2 has been shown to interact with PABPC1.[3]


  1. ^ Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220. 
  2. ^ a b "Entrez Gene: GSPT2 G1 to S phase transition 2". 
  3. ^ Hoshino, S; Imai M; Kobayashi T; Uchida N; Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. (UNITED STATES) 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005. 

Further reading[edit]