GSTA2

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Glutathione S-transferase alpha 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTA2 ; GST2; GSTA2-2; GTA2; GTH2
External IDs OMIM138360 HomoloGene47952 ChEMBL: 2241 GeneCards: GSTA2 Gene
EC number 2.5.1.18
Orthologs
Species Human Mouse
Entrez 2939 n/a
Ensembl ENSG00000244067 n/a
UniProt P09210 n/a
RefSeq (mRNA) NM_000846 n/a
RefSeq (protein) NP_000837 n/a
Location (UCSC) Chr 6:
52.61 – 52.63 Mb
n/a
PubMed search [1] n/a

Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.[1]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.[1]

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