GSTA3

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Glutathione S-transferase alpha 3
Protein GSTA3 PDB 1gsd.png
PDB rendering based on 1gsd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTA3 ; GSTA3-3; GTA3
External IDs OMIM605449 MGI95856 HomoloGene37355 ChEMBL: 4866 GeneCards: GSTA3 Gene
EC number 2.5.1.18
RNA expression pattern
PBB GE GSTA3 222102 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2940 14859
Ensembl ENSG00000174156 ENSMUSG00000025934
UniProt Q16772 P30115
RefSeq (mRNA) NM_000847 NM_001077353
RefSeq (protein) NP_000838 NP_001070821
Location (UCSC) Chr 6:
52.76 – 52.77 Mb
Chr 1:
21.24 – 21.27 Mb
PubMed search [1] [2]

Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene.[1][2][3]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.[3]

References[edit]

  1. ^ Suzuki T, Johnston PN, Board PG (Mar 1994). "Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes". Genomics 18 (3): 680–6. doi:10.1016/S0888-7543(05)80373-8. PMID 8307579. 
  2. ^ Board PG (Apr 1998). "Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4". Biochem J 330 (2): 827–31. PMC 1219212. PMID 9480897. 
  3. ^ a b "Entrez Gene: GSTA3 glutathione S-transferase A3". 

Further reading[edit]