GSTM2

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Glutathione S-transferase mu 2 (muscle)
Protein GSTM2 PDB 1hna.png
PDB rendering based on 1hna.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTM2 ; GST4; GSTM; GSTM2-2; GTHMUS
External IDs OMIM138380 MGI1915562 HomoloGene41816 ChEMBL: 4589 GeneCards: GSTM2 Gene
EC number 2.5.1.18
Orthologs
Species Human Mouse
Entrez 2946 68312
Ensembl ENSG00000213366 ENSMUSG00000004035
UniProt P28161 Q80W21
RefSeq (mRNA) NM_000848 NM_026672
RefSeq (protein) NP_000839 NP_080948
Location (UCSC) Chr 1:
110.21 – 110.25 Mb
Chr 3:
107.93 – 107.93 Mb
PubMed search [1] [2]

Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.[1][2][3]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.[3]

References[edit]

  1. ^ Vorachek WR, Pearson WR, Rule GS (Jun 1991). "Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus". Proc Natl Acad Sci U S A 88 (10): 4443–7. doi:10.1073/pnas.88.10.4443. PMC 51676. PMID 2034681. 
  2. ^ Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I (Jul 1990). "A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes". J Biol Chem 265 (16): 9188–93. PMID 2345169. 
  3. ^ a b "Entrez Gene: GSTM2 glutathione S-transferase M2 (muscle)". 

Further reading[edit]