GSTM3

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Glutathione S-transferase mu 3 (brain)
Protein GSTM3 PDB 3gtu.png
PDB rendering based on 3gtu.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTM3 ; GST5; GSTB; GSTM3-3; GTM3
External IDs OMIM138390 MGI1309466 HomoloGene658 ChEMBL: 2242 GeneCards: GSTM3 Gene
EC number 2.5.1.18
RNA expression pattern
PBB GE GSTM3 202554 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2947 14866
Ensembl ENSG00000134202 ENSMUSG00000004032
UniProt P21266 P48774
RefSeq (mRNA) NM_000849 NM_010360
RefSeq (protein) NP_000840 NP_034490
Location (UCSC) Chr 1:
110.28 – 110.28 Mb
Chr 3:
107.9 – 107.9 Mb
PubMed search [1] [2]

Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme which in humans is encoded by the GSTM3 gene.[1][2]

Function[edit]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including some carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.[1]

References[edit]

Further reading[edit]