GSTO1

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Glutathione S-transferase omega 1
Protein GSTO1 PDB 1eem.png
PDB rendering based on 1eem.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTO1 ; GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R
External IDs OMIM605482 MGI1342273 HomoloGene37971 ChEMBL: 3174 GeneCards: GSTO1 Gene
EC number 1.20.4.2, 1.8.5.1, 2.5.1.18
RNA expression pattern
PBB GE GSTO1 201470 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9446 14873
Ensembl ENSG00000148834 ENSMUSG00000025068
UniProt P78417 O09131
RefSeq (mRNA) NM_001191002 NM_010362
RefSeq (protein) NP_001177931 NP_034492
Location (UCSC) Chr 10:
106 – 106.03 Mb
Chr 19:
47.85 – 47.86 Mb
PubMed search [1] [2]

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[1][2][3]

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[3] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[4]

References[edit]

  1. ^ Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391. 
  2. ^ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics 13 (3): 131–44. doi:10.1097/01.fpc.0000054062.98065.6e. PMID 12618591. 
  3. ^ a b "Entrez Gene: GSTO1 glutathione S-transferase omega 1". 
  4. ^ Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the omega class of glutathione transferases". Meth. Enzymol. Methods in Enzymology 401: 78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN 978-0-12-182806-6. PMID 16399380. 

Further reading[edit]