GSTP1

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Glutathione S-transferase pi 1
Protein GSTP1 PDB 10gs.png
PDB rendering based on 10gs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTP1 ; DFN7; FAEES3; GST3; GSTP; PI
External IDs OMIM134660 MGI95864 HomoloGene660 ChEMBL: 3902 GeneCards: GSTP1 Gene
EC number 2.5.1.18
RNA expression pattern
PBB GE GSTP1 200824 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2950 14869
Ensembl ENSG00000084207 ENSMUSG00000038155
UniProt P09211 P46425
RefSeq (mRNA) NM_000852 NM_181796
RefSeq (protein) NP_000843 NP_861461
Location (UCSC) Chr 11:
67.35 – 67.35 Mb
Chr 19:
4.04 – 4.04 Mb
PubMed search [1] [2]

Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.[1][2]

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.[3]

Interactions[edit]

GSTP1 has been shown to interact with Fanconi anemia, complementation group C[4][5] and MAPK8.[6]

References[edit]

  1. ^ Bora PS, Bora NS, Wu XL, Lange LG (Oct 1991). "Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA". J Biol Chem 266 (25): 16774–7. PMID 1885604. 
  2. ^ Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (Nov 1995). "Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene". Cytogenet Cell Genet 71 (3): 235–9. doi:10.1159/000134117. PMID 7587384. 
  3. ^ "Entrez Gene: GSTP1 glutathione S-transferase pi". 
  4. ^ Cumming, R C; Lightfoot J; Beard K; Youssoufian H; O'Brien P J; Buchwald M (Jul 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nat. Med. (United States) 7 (7): 814–20. doi:10.1038/89937. ISSN 1078-8956. PMID 11433346. 
  5. ^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622. 
  6. ^ Wang, T; Arifoglu P; Ronai Z; Tew K D (Jun 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. (United States) 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. ISSN 0021-9258. PMID 11279197. 

Further reading[edit]

  • Strange RC, Fryer AA (1999). "The glutathione S-transferases: influence of polymorphism on cancer susceptibility.". IARC Sci. Publ. (148): 231–49. PMID 10493261. 
  • Kellen E, Hemelt M, Broberg K et al. (2007). "Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review". Am. J. Epidemiol. 165 (11): 1221–30. doi:10.1093/aje/kwm003. PMID 17404387. 
  • Sekine I, Minna JD, Nishio K et al. (2007). "A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1 (1): 31–7. doi:10.1097/01243894-200601000-00008. PMID 17409824.