GSTT1

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Glutathione S-transferase theta 1
Protein GSTT1 PDB 2c3n.png
PDB rendering based on 2c3n.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol GSTT1
External IDs OMIM600436 MGI107379 HomoloGene20235 ChEMBL: 2141 GeneCards: GSTT1 Gene
EC number 2.5.1.18
RNA expression pattern
PBB GE GSTT1 203815 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2952 14871
Ensembl ENSG00000184674 ENSMUSG00000001663
UniProt P30711 Q64471
RefSeq (mRNA) NM_000853 NM_008185
RefSeq (protein) NP_000844 NP_032211
Location (UCSC) Chr 22:
24.38 – 24.38 Mb
Chr 10:
75.78 – 75.8 Mb
PubMed search [1] [2]

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[1]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[2]

References[edit]

  1. ^ Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495. 
  2. ^ "Entrez Gene: GSTT1 glutathione S-transferase theta 1".