GSTT2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Glutathione S-transferase theta 2
Protein GSTT2 PDB 1ljr.png
PDB rendering based on 1ljr.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GSTT2 ; GSTT2B
External IDs OMIM600437 MGI106188 HomoloGene37358 GeneCards: GSTT2 Gene
EC number 2.5.1.18
Orthologs
Species Human Mouse
Entrez 2953 14872
Ensembl ENSG00000099984 ENSMUSG00000033318
UniProt P0CG30 Q61133
RefSeq (mRNA) NM_000854 NM_010361
RefSeq (protein) NP_000845 NP_034491
Location (UCSC) Chr 22:
24.3 – 24.3 Mb
Chr 10:
75.83 – 75.83 Mb
PubMed search [1] [2]

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.[1][2][3]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]

References[edit]

  1. ^ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971. 
  2. ^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J 334 (3): 617–23. PMC 1219731. PMID 9729470. 
  3. ^ a b "Entrez Gene: GSTT2 glutathione S-transferase theta 2". 

Further reading[edit]