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General transcription factor IIH, polypeptide 1, 62kDa
Protein GTF2H1 PDB 1pfj.png
PDB rendering based on 1pfj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GTF2H1 ; BTF2; P62; TFB1; TFIIH
External IDs OMIM189972 MGI1277216 HomoloGene3885 GeneCards: GTF2H1 Gene
RNA expression pattern
PBB GE GTF2H1 202451 at tn.png
PBB GE GTF2H1 202453 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2965 14884
Ensembl ENSG00000110768 ENSMUSG00000006599
UniProt P32780 Q9DBA9
RefSeq (mRNA) NM_001142307 NM_001291075
RefSeq (protein) NP_001135779 NP_001278004
Location (UCSC) Chr 11:
18.34 – 18.39 Mb
Chr 7:
46.8 – 46.82 Mb
PubMed search [1] [2]

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.[1][2][3]


GTF2H1 has been shown to interact with E2F1,[4] XPB,[5][6][7] ERCC2,[7][8] Estrogen receptor alpha,[9] Cyclin-dependent kinase 7[7][10][11] and TCEA1.[12][13]

See also[edit]


  1. ^ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science 257 (5075): 1392–5. doi:10.1126/science.1529339. PMID 1529339. 
  2. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum Mol Genet 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052. 
  3. ^ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa". 
  4. ^ Vandel, L; Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. (ENGLAND) 18 (15): 4280–91. doi:10.1093/emboj/18.15.4280. ISSN 0261-4189. PMC 1171504. PMID 10428966. 
  5. ^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9. doi:10.1038/ng1387. ISSN 1061-4036. PMID 15220921. 
  6. ^ Marinoni, J C; Roy R; Vermeulen W; Miniou P; Lutz Y; Weeda G; Seroz T; Gomez D M; Hoeijmakers J H; Egly J M (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. (ENGLAND) 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. ISSN 0261-4189. PMC 1169708. PMID 9118947. 
  7. ^ a b c Rossignol, M; Kolb-Cheynel I; Egly J M (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. (ENGLAND) 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. ISSN 0261-4189. PMC 1169767. PMID 9130708. 
  8. ^ Drapkin, R; Reardon J T; Ansari A; Huang J C; Zawel L; Ahn K; Sancar A; Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature (ENGLAND) 368 (6473): 769–72. doi:10.1038/368769a0. ISSN 0028-0836. PMID 8152490. 
  9. ^ Chen, D; Riedl T; Washbrook E; Pace P E; Coombes R C; Egly J M; Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell (UNITED STATES) 6 (1): 127–37. doi:10.1016/S1097-2765(00)00014-9. ISSN 1097-2765. PMID 10949034. 
  10. ^ Shiekhattar, R; Mermelstein F; Fisher R P; Drapkin R; Dynlacht B; Wessling H C; Morgan D O; Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature (ENGLAND) 374 (6519): 283–7. doi:10.1038/374283a0. ISSN 0028-0836. PMID 7533895. 
  11. ^ Yee, A; Nichols M A; Wu L; Hall F L; Kobayashi R; Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393. 
  12. ^ Archambault, J; Pan G; Dahmus G K; Cartier M; Marshall N; Zhang S; Dahmus M E; Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. (UNITED STATES) 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. ISSN 0021-9258. PMID 9765293. 
  13. ^ Pan, G; Aso T; Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. (UNITED STATES) 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. ISSN 0021-9258. PMID 9305922. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.