GTSE1

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G-2 and S-phase expressed 1
Identifiers
Symbols GTSE1 ; B99
External IDs OMIM607477 MGI1352755 HomoloGene8489 GeneCards: GTSE1 Gene
RNA expression pattern
PBB GE GTSE1 204315 s at tn.png
PBB GE GTSE1 204317 at tn.png
PBB GE GTSE1 204318 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51512 29870
Ensembl ENSG00000075218 ENSMUSG00000022385
UniProt Q9NYZ3 Q8R080
RefSeq (mRNA) NM_016426 NM_001168672
RefSeq (protein) NP_057510 NP_001162143
Location (UCSC) Chr 22:
46.69 – 46.73 Mb
Chr 15:
85.86 – 85.88 Mb
PubMed search [1] [2]

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.[1][2][3][4]

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.[4]

References[edit]

  1. ^ Monte M, Collavin L, Lazarevic D, Utrera R, Dragani TA, Schneider C (Oct 2000). "Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene". Gene 254 (1-2): 229–36. doi:10.1016/S0378-1119(00)00260-2. PMID 10974554. 
  2. ^ Collavin L, Monte M, Verardo R, Pfleger C, Schneider C (Oct 2000). "Cell-cycle regulation of the p53-inducible gene B99". FEBS Lett 481 (1): 57–62. doi:10.1016/S0014-5793(00)01969-4. PMID 10984615. 
  3. ^ Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C (Aug 2003). "The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function". J Biol Chem 278 (32): 30356–64. doi:10.1074/jbc.M302902200. PMID 12750368. 
  4. ^ a b "Entrez Gene: GTSE1 G-2 and S-phase expressed 1". 

Further reading[edit]