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Guanylate cyclase 1, soluble, beta 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GUCY1B3 ; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1
External IDs OMIM139397 MGI1860604 HomoloGene664 ChEMBL: 2046 GeneCards: GUCY1B3 Gene
EC number
RNA expression pattern
PBB GE GUCY1B3 211555 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2983 54195
Ensembl ENSG00000061918 ENSMUSG00000028005
UniProt Q02153 O54865
RefSeq (mRNA) NM_000857 NM_001161796
RefSeq (protein) NP_000848 NP_001155268
Location (UCSC) Chr 4:
156.68 – 156.73 Mb
Chr 3:
82.03 – 82.07 Mb
PubMed search [1] [2]

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[1][2]


Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2]


GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[3] and Endothelial NOS.[3]


  1. ^ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. 
  2. ^ a b "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3". 
  3. ^ a b Venema, Richard C; Venema Virginia J; Ju Hong; Harris M Brennan; Snead Connie; Jilling Tamas; Dimitropoulou Christiana; Maragoudakis Michael E; Catravas John D (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. (United States) 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. ISSN 0363-6135. PMID 12676772. 

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