GZMB

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Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Protein GZMB PDB 1fq3.png
PDB rendering based on 1fq3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GZMB ; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; HLP; SECT
External IDs OMIM123910 MGI109267 HomoloGene108184 IUPHAR: 2369 ChEMBL: 2316 GeneCards: GZMB Gene
EC number 3.4.21.79
RNA expression pattern
PBB GE GZMB 210164 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3002 14939
Ensembl ENSG00000100453 ENSMUSG00000015437
UniProt P10144 P04187
RefSeq (mRNA) NM_004131 NM_013542
RefSeq (protein) NP_004122 NP_038570
Location (UCSC) Chr 14:
25.1 – 25.1 Mb
Chr 14:
56.26 – 56.26 Mb
PubMed search [1] [2]

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[1] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[2]

See also[edit]

References[edit]

  1. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. 
  2. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.010