G protein-coupled bile acid receptor

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G protein-coupled bile acid receptor 1
Identifiers
Symbols GPBAR1 ; BG37; GPCR19; GPR131; M-BAR; TGR5
External IDs OMIM610147 MGI2653863 HomoloGene18125 IUPHAR: GPBA ChEMBL: 5409 GeneCards: GPBAR1 Gene
RNA expression pattern
PBB GE GPBAR1 gnf1h07596 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 151306 227289
Ensembl ENSG00000179921 ENSMUSG00000064272
UniProt Q8TDU6 Q80SS6
RefSeq (mRNA) NM_001077191 NM_174985
RefSeq (protein) NP_001070659 NP_778150
Location (UCSC) Chr 2:
219.12 – 219.13 Mb
Chr 1:
74.28 – 74.28 Mb
PubMed search [1] [2]

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene.[1]

Function[edit]

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This protein functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.[2]

One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.[3][4]

References[edit]

  1. ^ Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422. 
  2. ^ "Entrez Gene: GPBAR1 G protein-coupled bile acid receptor 1". 
  3. ^ Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006). "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation". Nature 439 (7075): 484–9. doi:10.1038/nature04330. PMID 16400329. 
  4. ^ Baxter JD, Webb P (2006). "Metabolism: bile acids heat things up". Nature 439 (7075): 402–3. doi:10.1038/439402a. PMID 16437098. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.