Gabaculine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gabaculine
Gabaculine.png
Identifiers
CAS number 87980-11-8
PubChem 3445
ChemSpider 3327
Jmol-3D images Image 1
Properties
Molecular formula C7H9NO2
Molar mass 139.15186
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis,[1] which acts as a potent and irreversible GABA transaminase inhibitor,[2][3] and also a GABA reuptake inhibitor.[4][5]

References[edit]

  1. ^ Kobayashi K, Miyazawa S, Endo A (April 1977). "Isolation and inhibitory activity of gabaculine, a new potent inhibitor of gamma-aminobutyrate aminotransferase produced by a Streptomyces". FEBS Letters 76 (2): 207–10. doi:10.1016/0014-5793(77)80153-1. PMID 862902. 
  2. ^ Rando RR (October 1977). "Mechanism of the irreversible inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase by the neurotoxin gabaculine". Biochemistry 16 (21): 4604–10. doi:10.1021/bi00640a012. PMID 410442. 
  3. ^ Irifune M, Katayama S, Takarada T, et al. (December 2007). "MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility". Can J Anaesth 54 (12): 998–1005. doi:10.1007/BF03016634. PMID 18056209. 
  4. ^ Allan RD, Johnston GAR, Twitchin B. Effects of Gabaculine on uptake, binding and metabolism of GABA. Neuroscience Letters. 1977;4:51-54.
  5. ^ Høg S, Greenwood JR, Madsen KB, Larsson OM, Frølund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP (2006). "Structure-activity relationships of selective GABA uptake inhibitors". Current Topics in Medicinal Chemistry 6 (17): 1861–82. doi:10.2174/156802606778249801. PMID 17017962.