Gaboxadol

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Gaboxadol
Gaboxadol.svg
Systematic (IUPAC) name
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one
Clinical data
Legal status ?
Identifiers
CAS number 64603-91-4 N
ATC code None
PubChem CID 3448
ChemSpider 3330 YesY
UNII K1M5RVL18S YesY
KEGG D04282 YesY
ChEMBL CHEMBL312443 YesY
Chemical data
Formula C6H8N2O2 
Mol. mass 140.14 g/mol
 N (what is this?)  (verify)

Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck.[1] In March, 2007, Merck and H. Lundbeck cancelled work on the drug, citing safety concerns and the failure of an efficacy trial. It acts on the GABA system, but possibly in a different way from benzodiazepines, nonbenzodiazepines and barbiturates - (Valium, Sodium Pentothal, Ambien etc.). Lundbeck states that gaboxadol also increases deep sleep (stage 4). It is, however, not reinforcing like benzodiazepines are.[2]

See also[edit]

References[edit]

  1. ^ US Patent 4278676 - Heterocyclic compounds
  2. ^ http://www.ncbi.nlm.nih.gov/pubmed/22496576

External links[edit]