Canizales turned pro in 1979 and in 1983 challenged Jeff Chandler for the World Boxing Association (WBA) bantamweight title but lost a decision. In 1986 he landed a shot at Richie Sandoval for the WBA bantamweight title. Canizales dominated, and knocked Sandoval down once in the 1st, once in the 3rd, and three times in the 7th round, winning via a 7th round knockout. He lost the belt in his first defense to Bernardo Pinango via decision. In 1990, he challenged Raúl Pérez for the World Boxing Council bantamweight title but lost a decision. In 1991, he challenged Miguel Lora for the vacant World Boxing Organization bantamweight title and won via 2nd round knockout. He lost the belt in his first defense to Duke McKenzie via decision, and retired after the loss.
The Orlando & Gaby Canizales Boxing Gym and Community Center on Guadalupe Street in Laredo is named in honor of the brothers. The facility was expanded in 2014.
|WBA Bantamweight Champion
10 March 1986 – 4 June 1986
|WBO Bantamweight Champion
12 March 1991 – 30 June 1991
- Malena Charur, "Orlando & Gaby Canizales Boxing Gym and Community Center: Brothers Honored: Facility Located on Guadalupe Street", Laredo Morning Times, May 2, 2014, p. 1
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