|Named for||Edmund Pendleton Gaines|
|• Total||1.8 sq mi (4.7 km2)|
|• Land||1.6 sq mi (4.0 km2)|
|• Water||0.3 sq mi (0.7 km2)|
|Elevation||574 ft (175 m)|
|• Density||562.5/sq mi (217.2/km2)|
|Time zone||Central (CST) (UTC-6)|
|• Summer (DST)||CDT (UTC-5)|
|GNIS feature ID||1285070|
Gainesboro is located at , approximately 15 miles northwest of Cookeville.(36.359705, -85.654657)
According to the United States Census Bureau, the town has a total area of 1.8 square miles (4.7 km2), of which 1.6 square miles (4.1 km2) are land and 0.3-square-mile (0.78 km2) (14.29%) is water.
As of the census of 2000, there were 879 people, 373 households, and 208 families residing in the town. The population density was 562.5 people per square mile (217.6/km²). There were 430 housing units at an average density of 275.2 per square mile (106.4/km²). The racial makeup of the town was 98.29% White, 1.98% African American, 0.11% Native American, 0.46% Asian, 0.34% from other races, and 0.80% from two or more races. Hispanic or Latino of any race were 0.57% of the population.
There were 373 households, of which 16.9% had children under the age of 18 living with them, 36.2% were married couples living together, 13.9% had a female householder with no husband present, and 44.0% were non-families. 38.6% of all households were made up of individuals and 18.5% had someone living alone who was 65 years of age or older. The average household size was 2.00 and the average family size was 2.61.
In the town the population was spread out with 13.5% under the age of 18, 8.8% from 18 to 24, 20.4% from 25 to 44, 26.6% from 45 to 64, and 30.7% who were 65 years of age or older. The median age was 51 years. For every 100 females there were 68.7 males. For every 100 females age 18 and over, there were 67.4 males.
The median income for a household in the town was $19,861, and the median income for a family was $30,250. Males had a median income of $24,091 versus $21,932 for females. The per capita income for the town was $17,798. About 20.3% of families and 27.8% of the population were below the poverty line, including 49.0% of those under age 18 and 25.7% of those age 65 or over.
The Gainesboro vicinity was a popular destination for long hunters as early as the 1770s, as natural salt licks drew rich game to the area. In the 1790s, Avery's Trace passed nearby, with travellers along the road lodging at Fort Blount about 10 miles to the west. Gainesboro was named after General Edmund Pendleton Gaines (1777–1849). It has been the seat of Jackson County since 1820.
- Charlotte Burks, Tennessee State Senator.
- Mounce Gore Butler - member of the United States House of Representatives.
- Alvan Cullem Gillem - Union army general.
- John J. Gore - United States District Court judge
- Laws of the State of Tennessee, Vol. 2 (Heiskell and Brown, 1821), p. 326.
- Tennessee Blue Book, 2005-2006, pp. 618-625.
- "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.
- "US Board on Geographic Names". United States Geological Survey. 2007-10-25. Retrieved 2008-01-31.
- "Find a County". National Association of Counties. Retrieved 2011-06-07.
- "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- The Federal Writers' Project, The WPA Guide to Tennessee (Knoxville, Tenn.: University of Tennessee Press, 1986), 445.