Galangin

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Galangin
Galangin structure
Identifiers
CAS number 548-83-4 YesY
PubChem 5281616
ChemSpider 4444935 YesY
UNII 142FWE6ECS YesY
KEGG C10044 YesY
ChEBI CHEBI:5262 YesY
ChEMBL CHEMBL309490 YesY
IUPHAR ligand 410
Jmol-3D images Image 1
Properties
Molecular formula C15H10O5
Molar mass 270.24 g/mol
Density 1.579 g/mL
Melting point 214–215 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Galangin is a flavonol, a type of flavonoid. It is found in high concentrations in Alpinia officinarum (lesser galangal)[1] and Helichrysum aureonitens.[2] It is also found in the galangal rhizome (Alpinia galanga)[3] and in propolis.[4] Galangin has been shown to have in vitro antibacterial[5][6] and antiviral activity.[7] The flavonol also inhibits the growth of breast tumor cells in vitro.[8][9]

See also[edit]

References[edit]

  1. ^ Ciolino, H. P.; Yeh, G. C. (1999). "The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor". British Journal of Cancer 79 (9/10): 1340–1346. doi:10.1038/sj.bjc.6690216.  edit
  2. ^ Afolayan AJ, Meyer JJ (1997). "The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens". Journal of Ethnopharmacology 57 (3): 177–181. doi:10.1016/s0378-8741(97)00065-2. PMID 9292410. 
  3. ^ Kaur, A.; Singh, R.; Dey, C. S.; Sharma, S. S.; Bhutani, K. K.; Singh, I. P. (2010). "Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd". Indian Journal of Experimental Biology 48 (3): 314–317. PMID 21046987.  edit
  4. ^ Tosi, E; Re, E; Ortega, M; Cazzoli, A (2007). "Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli". Food Chemistry 104: 1025. doi:10.1016/j.foodchem.2007.01.011.  edit
  5. ^ Cushnie TPT, Lamb AJ (2006). "Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus". Phytomedicine 13 (3): 187–191. doi:10.1016/j.phymed.2004.07.003. PMID 16428027. 
  6. ^ Cushnie TPT, Lamb AJ (2005). "Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss". Journal of Ethnopharmacology 101 (1-3): 243–248. doi:10.1016/j.jep.2005.04.014. PMID 15985350. 
  7. ^ Afolayan AJ, Meyer JJ, Taylor MB, Erasmus D (1997). "Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens". Journal of Ethnopharmacology 56 (2): 165–169. doi:10.1016/s0378-8741(97)01514-6. PMID 917497. 
  8. ^ So, F. V.; Guthrie, N.; Chambers, A. F.; Moussa, M.; Carroll, K. K. (1996). "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices". Nutrition and Cancer 26 (2): 167–181. doi:10.1080/01635589609514473. PMID 8875554.  edit
  9. ^ So, F.; Guthrie, N.; Chambers, A. F.; Carroll, K. K. (1997). "Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen". Cancer Letters 112 (2): 127–133. doi:10.1016/S0304-3835(96)04557-0. PMID 9066718.  edit

External links[edit]