Galanin-like peptide

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Galanin-like peptide
Identifiers
Symbol GALP
Entrez 85569
HUGO 24840
OMIM 611178
RefSeq NM_033106
UniProt Q9UBC7
Other data
Locus Chr. 19 q13.42

Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland.[1][2][3] It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.[4][5][6][7][8][9]

References[edit]

  1. ^ Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (February 2003). "Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis". Neuroendocrinology 77 (2): 125–31. doi:10.1159/000068648. PMID 12624534. 
  2. ^ Kageyama H, Takenoya F, Kita T, Hori T, Guan JL, Shioda S (March 2005). "Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction". Regulatory Peptides 126 (1-2): 21–6. doi:10.1016/j.regpep.2004.08.029. PMID 15620409. 
  3. ^ Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S (January 2008). "Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus". Regulatory Peptides 145 (1-3): 165–8. doi:10.1016/j.regpep.2007.08.019. PMID 17916390. 
  4. ^ Man PS, Lawrence CB (July 2008). "Galanin-like peptide: a role in the homeostatic regulation of energy balance?". Neuropharmacology 55 (1): 1–7. doi:10.1016/j.neuropharm.2008.04.008. PMID 18538801. 
  5. ^ Kuramochi M, Onaka T, Kohno D, Kato S, Yada T (April 2006). "Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat". Endocrinology 147 (4): 1744–52. doi:10.1210/en.2005-0907. PMID 16410310. 
  6. ^ Taylor A, Madison FN, Fraley GS (March 2009). "Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats". Journal of Chemical Neuroanatomy 37 (2): 105–11. doi:10.1016/j.jchemneu.2008.12.003. PMID 19124073. 
  7. ^ Man PS, Lawrence CB (November 2008). "Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide". Endocrinology 149 (11): 5791–802. doi:10.1210/en.2008-0252. PMC 3306896. PMID 18617619. 
  8. ^ Lawrence CB (July 2009). "Galanin-like peptide modulates energy balance by affecting inflammatory mediators?". Physiology & Behavior 97 (5): 515–9. doi:10.1016/j.physbeh.2009.02.041. PMID 19298833. 
  9. ^ Suzuki H, Onaka T, Dayanithi G, Ueta Y (June 2009). "Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland". Pathophysiology 17 (2): 135–140. doi:10.1016/j.pathophys.2009.03.007. PMID 19501488.