Galanin receptor 1

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Galanin receptor 1
Identifiers
Symbols GALR1 ; GALNR; GALNR1
External IDs OMIM600377 MGI1096364 HomoloGene74396 IUPHAR: GAL1 ChEMBL: 4894 GeneCards: GALR1 Gene
RNA expression pattern
PBB GE GALR1 220821 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2587 14427
Ensembl ENSG00000166573 ENSMUSG00000024553
UniProt P47211 P56479
RefSeq (mRNA) NM_001480 NM_008082
RefSeq (protein) NP_001471 NP_032108
Location (UCSC) Chr 18:
74.96 – 74.98 Mb
Chr 18:
82.39 – 82.41 Mb
PubMed search [1] [2]

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

See also[edit]

References[edit]

External links[edit]

  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.